氨来呫诺口腔贴片
Amlexanox Oral Mucoadhesive Patch
The FIRST-FDA APPROVED And ONLY AVAILABLE Prescription drug indicated spacifically for the treatment of Canker Sores
美国FDA批准的第一和唯一的治疗口腔溃疡的处方药
药物类别：
剂型：
适应症：
用于治疗免疫系统正常的成人及十二岁以上青少年的口腔溃疡
药理：
氨来呫诺口腔贴片经国内外临床多中心实验证明，可以阻止口腔溃疡的发作，加速愈合和缓解疼痛。氨来呫诺能缩短溃疡愈合时间，同时也减轻溃疡引起的疼痛。最新研究发现绝大多数的口腔溃疡患者，如能在口腔溃疡发作的前驱期（溃疡萌发期）使用氨来呫诺口腔贴片，可以阻断溃疡的发生。复发性口腔溃疡，又称阿弗它口腔溃疡或阿弗它口炎，是最常见的口腔粘膜疾病，发病率为20—25%，病人至少每年发生一次口腔溃疡。
作用机理：
作为苯并吡喃-吡啶羧酸衍生物，氨来呫诺具有抗炎，抗过敏的作用，能抑制化学介质引起的迟发性过敏反应，有拮抗白三烯等炎性物质的作用。
吸收：
口腔溃疡表面无明显吸收，大部分通过胃肠道吸收。
药物代谢：
代谢为羟基及其络合物。
禁忌：
对氨来呫诺和本品中其他成分过敏者禁用。
药物相互作用：
尚不明确。
（其余详见说明书）
Amlexanox Oral Mucoadhesive Patch
Drug Category
- Anti-Allergic Agents
- Antiulcer agent (topical)
- Anti-inflammatory, Locally Applied
Dosage Forms
- Oral Mucoadhesive patch (5%, 2mg)
Indications
Used as a patch in the mouth to treat aphthous ulcers (canker sores) in people who have a normal immune system and over 12 years old..
Pharmacology
Amlexanox is a mucoadhesive oral pacth which has been clinically proven to abort the onset, accelerate healing and resolve the pain of aphthous ulcers (canker sores). It decreases the time ulcers take to heal. Because amlexanox decreases the healing time, it also decreases the pain you feel. Recent studies have also shown that the majority of ulcers can be prevented by application of the paste during the prodromal (pre-ulcerative) phase of the disease. Recurrent Aphthous Ulcers (RAU) also known as Recurrent Aphthous Stomatitis (RAS) is recognized as the most common oral mucosal disease known to man. Estimates suggest that 20% - 25% of the general population suffer at least one incidence of aphthous ulcers each year.
Mechanism of Action
As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3.
Absorption
No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract.
Biotrnasformation / Drug Metabolism
Metabolized to hydroxylated and conjugated metabolites.
Contraindications
Hypersensitivity to amlexanox or any component of the formulation.
Drug Interactions
Not Available
（See details in the drug manual） |
